Perio Treatment & Cerebrovascular Function

University of Santiago de Compostela

Status: Enrolling

Conditions: Periodontitis

Treatments: Procedure: periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT05506917

PT-01

Details and patient eligibility

About

Periodontitis has been linked to increased risk of cerebrovascular disease. Impaired brain hemodynamics has been suggested as early markers of cerebral macro and microangiopathy. Therefore, the aim of this clinical trial will be to assess the potential effect of periodontal treatment on cerebral hemodynamics in otherwise healthy patients with severe periodontitis over 6 months.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Otherwise healthy subjects with severe periodontitis.

Exclusion criteria

• <10 teeth
• current smokers
• undergo periodontal treatment within the last 6 months.
• receive antibiotics or anti-inflammatory drugs within the last 3 months.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Periodontal treatment group

Experimental group

Description:

Patients will receive an intensive (non surgical) regimen of scaling and root planing of the root surfaces under local analgesia (depending on the severity in one session or two sessions within 2 days). Any tooth that from the baseline examination is defined as hopeless or irrational to treat will be extracted at the oral hygiene visit. After the 2 months re-assessment individuals if presenting with at least one periodontal pocket of 6 mm in depth will undergo additional corrective periodontal therapy consisting of periodontal surgery and re-instrumentation under local analgesia. If surgical periodontal therapy is not indicated, appropriate re-instrumentation of the sites will be performed.

Treatment:

Procedure: periodontal treatment