Periodonitis and Alzheimer's Disease

Universidade de Lisboa

Status: Not yet enrolling

Conditions: Periodontitis; Alzheimer Disease

Treatments: Diagnostic Test: Inflammatory mediators; Diagnostic Test: Periodontal Diagnosis; Diagnostic Test: Microbiological analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05189132

University Lisbon

Details and patient eligibility

About

The main objective of this study is to assess whether Periodontal Disease is more prevalent in adult patients diagnosed with Alzheimer's Disease compared to adult patients without Alzheimer's Disease.

The secondary objective is to describe and characterize the microbiological and biochemical profile of adult patients diagnosed with Alzheimer's Disease and compare with adult patients without Alzheimer's Disease.

Full description

To assess the possible association of Periodontal Disease with Alzheimer's Disease, I propose to carry out an observational, paired and cross-sectional study.

It will be evaluated whether adult patients diagnosed with Alzheimer's Disease have a higher prevalence of Periodontal Disease when compared to adult patients without Alzheimer's Disease.

As well, it will be evaluated whether adult patients with different stages of Alzheimer's disease have different stages of severity of Periodontitis.

The study sample will be obtained from the Associação Portuguesa de Alzheimer, in the Lisbon region, consisting of adult patients diagnosed with Alzheimer's Disease (test group).

The control group sample will consist of patients who attend consultations at the Faculty of Dental Medicine, University of Lisbon, matched for age, gender and other confounding factors, such as tobacco and systemic diseases (diabetes).

Enrollment: 134 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Will be included in the study all individuals who attend the Portuguese Alzheimer's Association, diagnosed with Alzheimer's Disease, who:

1. have voluntarily given their consent to participate;
2. due to cognitive or functional disability, they were unable to give free and informed consent, but they had this consent given by their representative
3. individuals who have participated in the cognitive assessment (only for the test group)

Exclusion criteria

• a) refused oral observation.

Trial design

134 participants in 2 patient groups

Test Group

Description:

Adult patients diagnosed with Alzheimer's disease

Treatment:

Diagnostic Test: Inflammatory mediators

Diagnostic Test: Microbiological analysis

Diagnostic Test: Periodontal Diagnosis

Control Group

Description:

The control group will consist of patients who attend consultations at the Faculty of Dentistry of the University of Lisbon, matched for age, gender and other confounding factors, such as smoking and systemic diseases (diabetes).

Treatment:

Diagnostic Test: Inflammatory mediators

Diagnostic Test: Microbiological analysis

Diagnostic Test: Periodontal Diagnosis