Periodontal Disease and Colorectal Cancer (PD and CRC)

University Medical Centre Ljubljana

Status: Completed

Conditions: Colorectal Carcinoma; Periodontal Diseases

Treatments: Procedure: periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT06799182

0120-486/2021/6 PB in KRK

Details and patient eligibility

About

The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer.

The main questions were:

1. Does periodontal treatment affect the levels of C-reactive protein in the blood of patients undergoing cancer treatment?
2. Can the investigators isolate periodontal pathogenic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis from the mucosa of cancerous colon tissue using the method of quantitative culture?

The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon.

Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• colorectal cancer, scheduled for surgical treatment
• consent to participate

Additional inclusion Criteria fot the control group:

• fiilled questionnaire
• Recorded CRP results at the first examination, after surgery, and at the first follow-up examination.

Exclusion criteria

• under 18 years old
• periodontal treatment in the past 12 months
• antibiotic therapy in the last 3 months
• edentulism
• advanced stage cancer, scheduled for palliative care
• chemotherapy or radiotherapy prior to surgical procedure

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Patients with colorectal cancer who recived periodontal treatment

Experimental group

Description:

Patients with colorectal cancer were treated for periodontal disease based on the condition of their periodontal tissues.

Treatment:

Procedure: periodontal treatment

Patients with colorectal cancer who did not recived periodontal treatment

No Intervention group

Description:

Due to ethical concerns, we selected patients who had completed cancer therapy before the start of our study for the control group, and who met the inclusion criteria based on the completed questionnaires.