PERIodontal Disease, Microbiota and Miscarriage (PERI2M)

Toulouse University Hospital

Status: Enrolling

Conditions: Parodontitis; Miscarriage

Treatments: Other: biological sampling

Study type: Observational

Funder types: Other

Identifiers

NCT06576622

RC31/24/0053

Details and patient eligibility

About

Cross-sectional non-interventional observational pilot study recruiting women whom had repeated miscarriages (= at least 3 miscarriages).The information will be collected during a routine maintenance, complete oral clinical and radiological examination (assessment carious, periodontal, mucosal and functional), which is part of the routine assessment in the service of odontology from Toulouse University Hospital.

Saliva and subgingival plaque samples, classically carried out in routine dental surgery as part of the health check-up oral, will be used to carry out bacterial assays.

Full description

Cross-sectional non-interventional observational pilot study recruiting women whom had repeated miscarriages (= at least 3 miscarriages).The information will be collected during a routine maintenance, complete oral clinical and radiological examination (assessment carious, periodontal, mucosal and functional), which is part of the routine assessment in the service of odontology from Toulouse University Hospital.

As part of the health check-up oral, Will be taken:

• Salivary samples by sputum (1 per patient). The patient will retain her saliva for 1 minute in the mouth and it will be collected in a sterile bottle (approximately 5 ml).
• Samples of subgingival plaque in the periodontal sulcus (assessed during periodontal probing) using sterile paper points (minimum 3 and maximum 10 per patient) inserted for 30 seconds into the periodontal sulcus then put in a tube sterile. The plate collection is done by capillary action on the paper tip, a very small quantity is thus taken.

A collection of the history and disease risk factors will then be carried out. periodontal problems (stress level assessed using the visual analogue scale, history personal and family periodontal diseases, oral hygiene habits, etc.) by a routine care interview, the clinical examination (visual examination and recording of oral and periodontal) and radiological examination.

Enrollment: 30 estimated patients

Sex: Female

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women whom had repeated miscarriages
• at least 6 natural teeth

Exclusion criteria

• under antibiotic prebiotic or probiotics treatment one month prior to the study
• with high infection risk (HIV,...)