Periodontal Infection and Systemic Inflammation in Renal Patients (PeriRen)

UConn Health

Status: Completed

Conditions: Chronic Kidney Disease; Periodontitis

Treatments: Procedure: Supragingival Prophylaxis; Procedure: Scaling root planing

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01094639

K23DE018689 (U.S. NIH Grant/Contract)

10-092-2

Details and patient eligibility

About

The purpose of this study is to examine the role of gum disease in affecting the long term prognosis of renal patients. This disease if untreated causes inflammatory response throughout the body. If the subject has gum disease, he/she will be randomly assigned to one of the two treatment groups. The study investigates what happens to inflammatory markers in blood and saliva after you are treated for gum disease.

Full description

The main goal of this project was to explore the contribution of chronic periodontitis to systemic inflammation in Chronic Kidney Disease (CKD). To achieve this goal, the project had two specific objectives:

1. a) To compare the prevalence of periodontal infection between CKD and non-CKD populations and b) to explore the association between the presence of periodontal infection and the uremic status of CKD patients.
2. a) To assess the levels of systemic inflammatory markers, IL-6 and CRP in the presence or absence of periodontal infection in CKD and b) to compare the serum IL-6 and CRP levels in response to periodontal intervention.

Enrollment: 52 patients

Sex: All

Ages: 21 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• dental subjects with periodontitis,
• at least 10 teeth
• no periodontal (gum) treatment for the last year,
• no antibiotic for the last 4 months,
• no vascular access infection.

Exclusion criteria

• smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 2 patient groups, including a placebo group

Supragingival prophylaxis

Placebo Comparator group

Description:

Plaque removal

Treatment:

Procedure: Supragingival Prophylaxis

Scaling root planing

Active Comparator group

Description:

SRP+oral hygiene

Treatment:

Procedure: Scaling root planing