Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Periodontal Disease; Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT02794012

15-2288

Details and patient eligibility

About

The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis. Subjects will undergo periodontal and joint examinations, as well as collection of body fluids to measure Rheumatoid Arthritis-related antibodies.

Enrollment: 146 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Rheumatoid Arthritis-antibody positivity (anti-CCP) in the absence of arthritis or
• Early RA <36 months since diagnosis

Exclusion criteria

• Pregnancy
• Antibiotic use prior to dental procedures or cleanings
• Wear dentures
• <18 years old

Trial design

146 participants in 4 patient groups

At-Risk Rheumatoid Arthritis subjects

Early Rheumatoid Arthritis subjects

Healthy Controls

Non-Rheumatoid Arthritis Autoimmune Controls