Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies

Istanbul Saglik Bilimleri University

Status: Completed

Conditions: Oral Bacteria; Endothelial Dysfunction; Biofilm; Periodontal Inflammation

Treatments: Other: atheroma plaque; Other: Dental plaque

Study type: Observational

Funder types: Other

Identifiers

NCT07165054

1

Details and patient eligibility

About

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.

Full description

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.

Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.

Enrollment: 51 patients

Sex: All

Ages: 25 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with endarterectomy
• Not receiving chemotherapy
• Not having received this treatment before

Exclusion criteria

• Having systemic infection
• Patients with severe heart disease

Trial design

51 participants in 1 patient group

Patients diagnosed with endarterectomy

Treatment:

Other: Dental plaque

Other: atheroma plaque