Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients

Saglik Bilimleri Universitesi

Status: Enrolling

Conditions: Pemphigus Vulgaris (PV); Periodontal Diseases

Treatments: Other: Clinical Periodontal and Oral Evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT07384221

2025-161

Details and patient eligibility

About

The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 years and older.
• Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.
• Presence of at least 10 natural teeth.
• Willingness to participate and signed informed consent.

Exclusion criteria

• Pregnancy or lactation.
• Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months.
• Periodontal treatment received within the last 6 months.

Trial design

20 participants in 1 patient group

Pemphigus Vulgaris Group

Description:

A comprehensive oral examination including ODSS scoring and periodontal measurements (PPD, CAL, PI, GI). Additionally, serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for biochemical correlation.

Treatment:

Other: Clinical Periodontal and Oral Evaluation