Periodontal Therapy in a Primary Prevention of Cardiovascular Disease

Macmillan Research Group UK

Status and phase: Completed; Phase 2

Conditions: Periodontitis; Coronary Disease

Treatments: Behavioral: Integrated Care Group; Other: Standard Care Group

Study type: Interventional

Funder types: Industry; Other

Identifiers

NCT02081976

Mac/Saibliss 2120

Details and patient eligibility

About

Cardiovascular diseases (CVD) are still considered the main cause of mortality and morbidity all over the world. In the last years, efforts have been made to define more effective therapeutic and preventive strategies.Periodontal diseases have been considered a probable risk factor for CVD with a great amount of evidence from observational studies. Although there are some interventional studies evaluating the systemic effects of periodontal therapy, there is little information regarding the impact of periodontal treatment on the prevention of cardiovascular events. To the best of our knowledge, there are no randomized controlled trials published to date assessing the effect of periodontal therapy in primary prevention of CVD.

Enrollment: 57 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals having at least 50% of their dentition with periodontal probing pocket depths N4 mm and
• With documented radiographic alveolar bone loss were included

Exclusion criteria

• Known systemic diseases
• History and/or presence of other infections
• Systemic antibiotic treatment in the preceding 3 months
• Treatment with any medication known to affect the serum level of inflammatory markers, lipids, or BP
• Pregnant or lactating females
• Allergy to tetracyclines

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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57 participants in 2 patient groups

Standard Care Group

Active Comparator group

Description:

Dental therapist providing standard periodontal treatment

Treatment:

Other: Standard Care Group

Integrated Care Group

Experimental group

Description:

a combined treatment approach of Dental Therapist, Dental Hygienist, Cardiologist along with counselor

Treatment:

Behavioral: Integrated Care Group