Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease

University of Turin

Status: Enrolling

Conditions: Dysbiosis; Inflammation; Periodontal Diseases; IBD

Treatments: Procedure: Full mouth scaling and root planing (FMSRP)

Study type: Interventional

Funder types: Other

Identifiers

NCT04790825

IBD-perio project

Details and patient eligibility

About

Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored. Oral-gut axis is implicated in the pathogenesis of several chronic inflammatory conditions, but to date no studies have evaluated the impact of periodontal treatment on gut ecology. Thus, the present randomised clinical trial is aimed at investigating the effect of intensive or conventional periodontal therapy on the gut microbiome and parameters of systemic inflammation of patients diagnosed with inflammatory bowel disease.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical and instrumental diagnosis of ulcerative colitis or Crohn's disease
• periodontitis Stage III or IV
• BMI between 20 and 29 kg/m2
• free diet
• presence of at least 20 teeth

Exclusion criteria

• Systemic diseases (including diabetes, thyroid, liver, or kidney diseases)
• dietary allergies
• use of antibiotics or probiotics during the previous 30 days
• pregnancy or breast feeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Intensive periodontal treatment

Experimental group

Description:

Adjunctive full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planing after the administration of local anesthesia.

Treatment:

Procedure: Full mouth scaling and root planing (FMSRP)

Community-based periodontal care

Active Comparator group

Description:

Standard cycle of supragingival mechanical scaling and polishing.

Treatment:

Procedure: Full mouth scaling and root planing (FMSRP)