Periodontally Accelerated Osteogenic Orthodontics With BMP2

SVS Institute of Dental Sciences

Status and phase: Completed; Phase 2

Conditions: Malocclusion

Treatments: Drug: RhBMP-2 Protein, Recombinant; Other: Conventional Corticotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT03396900

SVSIDS/PERIO/2/2015

Details and patient eligibility

About

rhBMP-2 has the potential to function as a regenerative material in periodontally accelerated osteogenic orthodontics (PAOO). This study aimed to assess the effects of PAOO with BMP-2 on outcomes such as treatment period, bone density, healing and pain.

Full description

Subjects were randomly assigned into each of the following experimental groups; C+BMP: corticotomy with 0.5 μg/mL rhBMP-2 and C: corticotomy only. Clinical parameters included recording the duration of treatment period, visual analogue scale (VAS) scores and early healing index (EHI) scores. The evaluation of bone density was performed at baseline, 3 months and 6 months by using RVG.

Enrollment: 30 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 30 subjects with moderate crowding of lower incisors based upon Little's index and willing to undergo undergoing orthodontic treatment with extraction therapy of lower 1st premolars and PAOO were included in the study.

Exclusion criteria

• Smokers and subjects with severe crowding of anterior teeth, periodontitis and systemic diseases were excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups

RhBMP-2 Protein, Recombinant

Active Comparator group

Description:

15 subjects treated with corticotomy with rhBMP-2 (C+BMP)

Treatment:

Drug: RhBMP-2 Protein, Recombinant

Conventional Corticotomy

Experimental group

Description:

15 subjects treated with conventional corticotomy (C) as in the PAOO protocol

Treatment:

Other: Conventional Corticotomy