Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction

Prince of Songkla University

Status and phase

Completed

Phase 4

Conditions

Postoperative Pain Management

Treatments

Drug: Pregabalin

Study type

Interventional

Funder types

Other

Identifiers

NCT01242332

EC 52 -234-08-1-2

Details and patient eligibility

About

To prove pregabalin's efficacy and safety in Thai patients scheduled for arthroscopic ACL reconstruction

Full description

Only eligible patients with willingness to join this study are included. Eligible patients are those aged 18-65 years of either sex, American Society of Anesthesiologists (ASA) physical status I & II, and body mass index (BMI) between 16-35. The exclusion criteria are patients who are allergic to pregabalin, with impaired hepatic and renal functions, alcohol or substance abuse, chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus) and inability to operate patient-controlled analgesia (PCA) device.

Data analysis

Student t-test for continuous data with normal distribution
Mann-Whitney U test for continuous data with non-normal distribution
Chi-square test for categorical data

Enrollment

60 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Eligible patients are those aged 18-65 years of either sex,
American Society of Anesthesiologists (ASA) physical status I & II, and body mass index (BMI) between 16-35.

Exclusion criteria

patients who are allergic to pregabalin,
impaired hepatic and renal functions,
alcohol or substance abuse,
chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus)
inability to operate patient-controlled analgesia (PCA) device