Perioperative Cognitive Training in Thoracic Surgery (COFLEX-T)

The Washington University

Status: Withdrawn

Conditions: Pain, Postoperative; Lung Cancer; Cognitive Function Abnormal

Treatments: Behavioral: COFLEX neurocognitive training; Behavioral: Crossword puzzles

Study type: Interventional

Funder types: Other

Identifiers

NCT04563234

202007033

Details and patient eligibility

About

More than 30% of patients undergoing thoracic surgical procedures develop persistent post-surgical pain (PPSP), which results in impaired functioning, diminished quality of life, and increased risk of chronic opioid use. The proposed project aims to determine whether a prospective, randomized, controlled study of smartphone-based perioperative cognitive flexibility training will reduce the incidence of PPSP in high-risk individuals undergoing thoracic surgery.

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults age 18 to 75 undergoing thoracic surgery
• Access to an active email account
• Score <50th percentile on Color Word Matching Stroop Test (CWMST) normalized T-score

Exclusion criteria

• Unable to complete cognitive testing
• Color blindness assessed via self-report
• Participants who do not speak or read English

The inclusion criteria for the observational cohort will be the same, with the exception of Score ≥50th percentile on Color Word Matching Stroop Test (CWMST) normalized T-score.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups

COFLEX training

Experimental group

Description:

Neurocognitive training, delivered via a mobile device app

Treatment:

Behavioral: COFLEX neurocognitive training

Crossword group

Active Comparator group

Description:

Access to crossword puzzles via a mobile device app

Treatment:

Behavioral: Crossword puzzles