Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery (POETRYminor)

Z

Zealand University Hospital

Status

Completed

Conditions

Myocardial Injury

Treatments

Procedure: Elective Surgery

Study type

Observational

Funder types

Other

Identifiers

NCT02690233
POETRY minor

Details and patient eligibility

About

This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period. The aim of this explorative and observational clinical study is to closely examine the endothelial function and its dynamics in the early postoperative period after minor surgery (lap. inguinal hernia repair). The endothelial function will be assessed indirectly by EndoPat and plasma biomarkers of nitric oxide bioavailability. The study will contribute to the understanding of perioperative myocardial injury, which is crucial for optimized treatment of patients at risk of cardiovascular complications.

Full description

The investigators will include 60 patients undergoing elective inguinal hernia repair. The endothelial function will be measured before surgery and 4 hours after surgery with the EndoPat system. The NO-bioavailibility will be measured by plasma l-arginine, plasma ADMA and plasma biopterins.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled for a laparoscopic inguinal hernia repair
  • Patients ≥ 18 years old

Exclusion criteria

  • Not capable of giving informed consent after oral and written information
  • Previously included in the trial  - Surgery within 7 days of the trial

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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