Perioperative Fluid Therapy in Patients Undergoing Pancreaticoduodenectomy

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Postoperative Complications

Treatments: Other: Liberal fluid therapy; Other: Goal directed fluid therapy

Study type: Observational

Funder types: Other

Identifiers

NCT04687826

GDFT1517

Details and patient eligibility

About

Postoperative complication rates in patients undergoing pancreaticoduodenectomy remain high although the operation techniques have developed a lot in recent years. There is evidence that restrictive intraoperative fluid therapy could decrease postoperative complication rates but the results of the former studies have been somewhat controversial. The aim of this study is to examine whether the intraoperative and postoperative fluid therapy affect to the postoperative complication rates in patients undergoing pancreaticoduodenectomy.

Full description

The study is a retrospective cohort study. The first cohort consists of patients who underwent pancreaticoduodenectomy in year 2015 when intraoperative fluid therapy were managed using goal directed fluid therapy technique. The second cohort consists of patients who underwent pancreaticoduodenectomy in year 2017 when intraoperative fluid therapy were based on the consideration of the anaesthesiologist. In 2015 most of the patients spent the first postoperative night in the ICU where the fluid management and monitoring of the urine output and vital functions were more controlled than in the normal ward. In 2017 most of the patients got in the regular ward right after the surgery. The aim of the study is to examine whether there are differences in the amounts of the intraoperative and postoperative fluids between the cohorts and does the perioperative fluid therapy affect to the complication rates.

Enrollment: 168 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 or over
• patients who underwent pancreaticoduodenectomy in 2015 or in 2017

Exclusion criteria

• patients whose patient record information is insufficient

Trial design

168 participants in 2 patient groups

Pancreaticoduodenectomy in 2015

Description:

Patients who underwent pancreaticoduodenectomy in 2015 got intraoperative fluid therapy in goal directed fluid therapy technique. Most of the patients spent the first postoperative night in ICU where the monitoring of urine output and fluid balance are more specific than in a normal ward.

Treatment:

Other: Goal directed fluid therapy

Pancreaticoduodenectomy in 2017

Description:

Patients who underwent pancreaticoduodenectomy in 2017 got liberal intraoperative fluid therapy and most of the patients spent the first postoperative night in a regular ward.

Treatment:

Other: Liberal fluid therapy