Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Non-Cardiac Surgery Patients

Chinese PLA General Hospital (301 Hospital)

Status: Completed

Conditions: Mortality; Elderly; Postoperative; AKI - Acute Kidney Injury; Homocysteinemia

Study type: Observational

Funder types: Other

Identifiers

NCT06959446

PLAGH-AOC-L07

Details and patient eligibility

About

This study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy levels may reflect metabolic shifts, highlighting their potential value in predicting adverse postoperative outcomes. These findings suggest that monitoring perioperative Hcy levels and their changes could help identify high-risk patients and inform postoperative management strategies.

Enrollment: 12,955 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized older (≥ 65 years) patients underwent non-cardiac surgery

Exclusion criteria

• 21227 patients without preoperative Hcy data
• 957 patients undergoing neurosurgery
• 3 patients call off the surgery for reasons
• 164 patients with chronic kidney disease