Perioperative Lactate Kinetics in Patient Undergoing Major Liver Surgery

Institutul Clinic Fundeni

Status: Completed

Conditions: Liver Failure, Acute

Treatments: Diagnostic Test: serum lactate

Study type: Observational

Funder types: Other

Identifiers

NCT04512014

Liver_lactate

Details and patient eligibility

About

Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.

Enrollment: 55 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing major liver surgery for primary or secondary tumours

Exclusion criteria

• unsigned patient consent
• death within 24 hours
• need for perioperative renal replacement therapy
• underlying liver disease (e.g. liver cirrhosis)
• other causes of raised lactate levels (e.g. shock)

Trial design

55 participants in 1 patient group

major liver surgery

Description:

Patients undergoing major liver surgery

Treatment:

Diagnostic Test: serum lactate