Perioperative Lung Function Monitoring After Anatomic Lung Resections (PLF)

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Lung Diseases; Surgery; Lung Function Decreased

Treatments: Diagnostic Test: Spirometry

Study type: Observational

Funder types: Other

Identifiers

NCT03054675

266/15

Details and patient eligibility

About

Aim of this study was to prospectively investigate the correlation between postoperative spirometry values and pulmonary complications after anatomic lung resections. In addition, the investigators compared postoperative pulmonary function changes between open and minimally invasive approaches.

Full description

All patients undergoing an anatomical lung resection at the investigators' institution were evaluated for this study. Underage patients and those undergoing extended resections (including resection of the chest wall and/or diaphragm) and/or bronchoplastic procedures were excluded.

In every eligible patient undergoing an anatomic lung resection, preoperative spirometry was performed using a handheld spirometer on the day before surgery and on every second day after surgery was performed until patient discharge. The absolute values of FEV1 were recorded by an independent study nurse and noted on a separate sheet not available to the treating doctors.

At the end of the study period FEV1 values were evaluated especially with focus on their correlation with postoperative pulmonary complications (i.e. pneumonia, acute exacerbation of COPD, air leak and atelectasis). Furthermore lung function values of patients undergoing 'open' resections were compared with patients undergoing minimally invasive resections.

Enrollment: 328 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing anatomical lung resection
• Written informed consent

Exclusion criteria

• Underage patients
• Extended resections including resection of chest wall or diaphragm
• Bronchoplastic resections

Trial design

328 participants in 4 patient groups

Pneumonia

Description:

Patients suffering from postoperative pneumonia including all three of the following: 1. Clinical signs of a pulmonary infection (i.e. fever ≥ 38°C combined with productive cough and/or dyspnea) 2. A new rise of inflammatory markers (i.e. WBC count ≥ 10.5 x 109 and elevated CRP) 3. New radiographic infiltrates on chest x-ray without another explanation. Patients with pneumonia undergo spirometry before and on every second day after lung surgery

Treatment:

Diagnostic Test: Spirometry

No Pneumonia

Description:

Patients without pneumonia undergo spirometry before and on every second day after lung surgery

Treatment:

Diagnostic Test: Spirometry

Open (no pneumonia)

Description:

Patients undergoing open anatomical lung resection who did not show postoperative pneumonia. All patients undergo spirometry before and on every second day after lung surgery.

Treatment:

Diagnostic Test: Spirometry

Minimally invasive (no pneumonia)

Description:

Patients undergoing minimally invasive anatomical lung resection who did not show postoperative pneumonia. All patients undergo spirometry before and on every second day after lung surgery.

Treatment:

Diagnostic Test: Spirometry