Perioperative Muscle Relaxant and Postoperative Outcomes (POMPO)

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Postoperative Complications

Treatments: Other: 1-2 Response to Train of Four Stimulation; Other: No Response to Train of Four Stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT04371588

XJH-A-20290110

Details and patient eligibility

About

Muscle relaxant is usually needed for surgery. However, the optimal depth of neuro-muscular blockade is still on debate. Deep neuro-muscular blockade may benefit the patients during surgery, but may increase the risk of residual blockade after surgery. Residual blockade has been reported to increase risk of morbidity. In this study, we tend to observe the postoperative outcomes in patients undergoing abdominal surgery under general anesthesia. And to compare the outcomes in patients received different depth of neuro-muscular blockade.

Enrollment: 999 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years old
• Body mass <18 kg/m2
• American Society of Anesthesiologists status I-II
• Patients scheduled for elective laparoscopic colorectal or urological surgery
• Patients received general anesthesia and muscle relaxant
• Patients with written informed consent.

Exclusion criteria

• Second surgery during the same admission.
• Outpatient surgery
• Retroperitoneal laparoscopic surgery
• Patients scheduled for mechanical ventilation after surgery
• Patients scheduled for muscle relaxant other than rocuronium
• Patients with pregnancy or planned for breeding
• Patients who are involved in other studies

Trial design

999 participants in 2 patient groups

Deep neuro-muscular blockade

Treatment:

Other: No Response to Train of Four Stimulation

Moderate neuro-muscular blockade

Treatment:

Other: 1-2 Response to Train of Four Stimulation