Perioperative Neuroprotection of Stellate Ganglion Block

General Hospital of Ningxia Medical University

Status: Unknown

Conditions: Intracranial Aneurysm

Treatments: Drug: Stellate Ganglion Block

Study type: Interventional

Funder types: Other

Identifiers

NCT02275247

NXKJGG2014

Details and patient eligibility

About

To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery

Full description

The vasospasm after cranial aneurysm surgery have a higher incidence, but not have an ideal treatment method. At present, the medical treatment is very limited effect to prevent the perioperative cerebral ischemia.Stellate ganglion block （SGB）is an effective and well-tolerated approach to the treatment of CVS in various clinical settings.Resent study indicated that SGB has a protective effect on delayed cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage.Therefore,we hypothesized that the preoperative SGB would be a effective treatment for improvement of vasospasm after cranial aneurysm surgery.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aneurysm subarachnoid hemorrhage patients scheduled for cranial aneurysm surgery，
• ASA grade：Ⅱ-Ⅲ，
• Hunt～Hess grade :Ⅰ-Ⅲ,
• have a informed consent.

Exclusion criteria

• history of mental illness，
• local infection who can't do stellate ganglion block，
• pregnant or lactating，
• nausea cancer or diabetes，
• participated the study or other related research in the last 30 days，
• unruptured aneurysms patients

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Intervention 'Stellate Ganglion Block'

Experimental group

Description:

Experimental patients will receive a stellate ganglion block with 0.25% ropivacaine 6-8mL on the right side at the level of the sixth cervical vertebrae (C6) before surgery.Then the catheter will be attached to a single use patient-controlled analgesia pump containing 0.2% ropivacaine 150 mL, which will be infused at 2 mL/h.

Treatment:

Drug: Stellate Ganglion Block

without 'Stellate Ganglion Block'

No Intervention group

Description:

In the control group, every thing will be conducted as a matter of routine without intervention.