Perioperative Outcomes of Simultaneous Colorectal and Liver Resections (SIMULT)

Fondazione Poliambulanza Istituto Ospedaliero

Status: Completed

Conditions: Surgical Procedure, Unspecified; Colorectal Cancer Metastatic

Treatments: Procedure: Technically major liver resection; Procedure: Major liver resection

Study type: Observational

Funder types: Other

Identifiers

NCT05475041

NP5467

Details and patient eligibility

About

The use of a simultaneous resection in patients with synchronous colorectal liver metastases has increased over the past decades. However, it remains unclear when a simultaneous resection is beneficial and when it should be avoided. The objective of this retrospective study is therefore to compare the outcomes of a simultaneous resection for synchronous colorectal liver metastases in different settings, and to assess which factors are independently associated with unfavorable outcomes.

Enrollment: 766 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective minimally invasive or open simultaneous resection of colorectal cancer and synchronous colorectal liver metastases

Exclusion criteria

• (Partially) robotic-assisted or thoracoscopic procedures
• First stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)
• Patients that underwent major concurrent procedures

Trial design

766 participants in 3 patient groups

Minor liver resection

Description:

Minor liver resection (\<3 contiguous segments) in the anterolateral segments

Technically major liver resection

Description:

Minor liver resection (\<3 contiguous segments) in the posterosuperior segments (Segment 1,4a,7,8)

Treatment:

Procedure: Technically major liver resection

Major liver resection

Description:

Major liver resection (3 or more contiguous segments)

Treatment:

Procedure: Major liver resection