Perioperative Protective Effects of Lidocaine

University Hospital Muenster

Status and phase: Terminated; Phase 3; Phase 2

Conditions: Elective Surgical Procedure; Colorectal Surgery

Treatments: Drug: NaCl 0,9%; Drug: lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT00413127

06-AnIt-06

Details and patient eligibility

About

The purpose of this study is to comparing effects of intravenously (IV) administered lidocaine to effects of epidurally (ED) administered lidocaine in patients undergoing elective colorectal surgery

Enrollment: 78 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective colorectal surgery

Exclusion criteria

• ASA > 3
• history of anti-inflammatory therapy
• history of inflammatory bowl diseases
• history of chronic pain treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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78 participants in 5 patient groups, including a placebo group

1

Experimental group

Description:

Lidocaine i.v

Treatment:

Drug: lidocaine

2

Active Comparator group

Description:

intraoperatively lidocaine epidural postoperatively lidocaine i.v.

Treatment:

Drug: lidocaine

3

Active Comparator group

Description:

intraoperatively lidocaine i.v. postoperatively lidocaine epidural

Treatment:

Drug: lidocaine

4

Active Comparator group

Description:

lidocaine epidural

Treatment:

Drug: lidocaine

5

Placebo Comparator group

Description:

placebo i.v.

Treatment:

Drug: NaCl 0,9%