Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy

University of Pecs

Status: Completed

Conditions: Carotid Stenosis; Ischemia Reperfusion Injury

Treatments: Procedure: Carotid artery stenting; Procedure: Carotid endarterectomy

Study type: Observational

Funder types: Other

Identifiers

NCT03410576

5016

Details and patient eligibility

About

The aim was the comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during elective carotid artery stenting (CAS). The investigators used a matched, historical carotid endarteriectomy group as controls. Blood samples at four time points: T1: preoperative; T2: 60 minutes after stent insertion; T3: first postoperative morning; and T4: third postoperative morning. Plasma was isolated from heparin anticoagulated blood samples by low speed centrifugation at 4 °C, and stored at -80 °C until analyzed in a single batch at the end of the study. Plasma concentrations of MMP-9 and TIMP-1 were expressed as ng/ml.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

elective carotid artery surgery

Exclusion criteria

Malignant diseases, inflammatory and systemic autoimmune disorders, psychiatric disorders and previous debilitating stroke

Trial design

25 participants in 2 patient groups

Carotid artery stenting

Description:

Patients undergo carotid artery stenting.

Treatment:

Procedure: Carotid artery stenting

Carotid endarterectomy

Description:

Patients receive elective carotid endarterectomy.

Treatment:

Procedure: Carotid endarterectomy