Perioperative Troponin I and NT Pro-BNP in Lung Resection

Vall d'Hebron University Hospital (HUVH)

Status: Completed

Conditions: Complication,Postoperative; Cardiac Ischemia; Thoracic Cancer

Treatments: Diagnostic Test: serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)

Study type: Observational

Funder types: Other

Identifiers

NCT04749212

621/2020

Details and patient eligibility

About

After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. Integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.

Full description

Objectives: To evaluate the incidence and magnitude of perioperative N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (Tn I) elevation in patients undergoing pulmonary resection and its predictive value for cardiovascular complications. Methodology: Prospective, multicenter, observational cohort study in patients >45 years undergoing elective thoracic surgery for lung resection. Cardiac biomarkers Tn I and NT-proBNP will be measured preoperatively and at postoperative days 1 and 2. Risk score for major cardiovascular postoperative complications will be calculated depending of both biomarkers perioperative changes.

Enrollment: 475 patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥45 years old
• Patients undergoing elective surgery for lung resection

Exclusion criteria

• Patients undergoing urgent, emergent, or nonthoracic surgery
• Patients or family did not consent to participate
• Presence of symptoms related with infection or sepsis
• Patients with a documented history of severe heart failure and/or ejection fraction lower than 30%