Periostin and Non-Surgical Periodontal Treatment

Kırıkkale University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Procedure: Non-Surgical Periodontal Treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04332965

2017/43

Details and patient eligibility

About

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Full description

Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.

This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Enrollment: 90 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of chronic periodontitis
• Clinical diagnosis of gingivitis
• Clinical diagnosis of periodontal health

Exclusion criteria

• have any systemic disease
• to be alcohol consumer
• to receive any periodontal therapy in the past 6 months
• to take any drugs regularly
• to be pregnant and/or lactate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

Patients with chronic periodontitis

Experimental group

Description:

Patients with CP (n=30) had teeth with 30% periodontal bone loss and ≥ 2 non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and bleeding on probing.

Treatment:

Procedure: Non-Surgical Periodontal Treatment

Patients with gingivitis

Experimental group

Description:

Participants with G (n=30) had gingival index ≥ 2 and other inflammation signs.

Treatment:

Procedure: Non-Surgical Periodontal Treatment

Participants with periodontal healthy

No Intervention group

Description:

The H group (n=30) consisted of individuals with no attachment loss, no history of periodontal disease, PD ≤3 mm, and whole-mouth bleeding scores \<10%.