Peripheral Arterial Disease Biomarkers (PADBIRD)

Norfolk and Norwich University Hospitals NHS Foundation Trust

Status: Not yet enrolling

Conditions: Peripheral Arterial Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06373302

IRAS 323948

Details and patient eligibility

About

The study aims to determine how expression levels of biomarkers for peripheral arterial disease change over time in response to exercise therapy, surgical or endovascular intervention, and whether they can be used to predict disease progression.

Full description

Several studies have identified markers in the blood (called biomarkers) that are associated with peripheral arterial disease, or clogging up of the blood supply to the leg. There is little understanding however regarding how these respond to intervention, and how they are related to walking distance.

This study will increase the understanding of the relationship between peripheral arterial disease state and biomarker expression and enable us to work towards the development of new targets for treatment.

Participants will be invited to undertake questionnaires and dedicated walking tests alongside regular blood tests to check their biomarker levels. These will be undertaken on a regular basis so the investigators can see what happens over time, such as after a surgical procedure, and see if these markers go back towards normal following intervention.

Enrollment: 100 estimated patients

Sex: All

Ages: 50 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged > 50 years
• Symptomatic PAD
• ABPI <0.8 or TBPI <0.7

Exclusion criteria

• Aged <50 years
• Current Malignancy
• Rheumatological Condition
• Previous surgical or endovascular intervention for PAD
• ABPI >0.8 or TBPI >0.7

Trial design

100 participants in 2 patient groups

Exercise Therapy

Description:

Patients who are advised by their clinician to undertake exercise therapy as their treatment for peripheral arterial disease

Angioplasty

Description:

Patients undergoing angioplasty for treatment of peripheral arterial disease, as advised by their clinician.