Peripheral Artery Disease (PAD) : Its Effects on Bone (AMICOS)

Centre Hospitalier Régional d'Orléans

Status

Terminated

Conditions

Peripheral Artery Disease

Bone

Treatments

Procedure: Assessment of BMD by DXA and HRpQCT

Study type

Interventional

Funder types

Other

Identifiers

NCT05034848

CHRO-2018-13

Details and patient eligibility

About

Prevalence of PAD and osteoporosis (OP) both get higher with age. Clinical and epidemiologic evidence have showed an increased cardiovascular risk in OP and bone loss and fragility fractures in patient with cardiovascular disease.

This study will examine the relationship between vascular disease in legs and sBMD and vBMD at trabecular and cortical sites and bone microarchitecture.

Full description

The primary goal of our study is to determinate if presence of PAD is associated with lower sBMD and vBMD values at the tibias, assuming that BMD should be more alterate in the predominant vascular impairement site.

Our secondary objectives are to :

determine if severity of PAD quantified by ankle brachial index ABI is associated to a decrease of BMD values defined by T-Score at the left hip, spine and legs, but also with volumetric values, assessed by HRpQCT at the non dominant radius and at both tibias.
determine the prevalence of osteoporosis in our population
To evaluate the relationships between ;
lipids and bone parameters
vit D and parathormone with PAD severity
levels of physical activity and both vascular and bone impairments

Enrollment

2 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

PAD patients defined by an Ankle brachial index < 0.9
Written consent
Patient affiliated with a social security organism

Exclusion criteria

Age < 18 years
Pregnancy or risk of pregnancy
Patients Under guardianship
Patient with known PAD who had been previously treated by surgery or endovascular pathway