Peripheral Effects of Endotoxin on Insulin Resistance

Aarhus University Hospital

Status: Completed

Conditions: Healthy

Treatments: Biological: USP endotoxin

Study type: Interventional

Funder types: Other

Identifiers

NCT00929136

Aarhus University Hospital

Details and patient eligibility

About

The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

Enrollment: 8 estimated patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Normal health
2. 22 < BMI < 28
3. Written Informed Concent

Exclusion criteria

1. Any disease
2. Any use of medication
3. Recent immobilization of a lower extremity

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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8 participants in 1 patient group

Endotoxin

Experimental group

Treatment:

Biological: USP endotoxin