Peripheral Nerve Ultrasound for Diagnosis and Prognosis of Guillain-Barre Syndrome

Duke University

Status: Terminated

Conditions: Guillain-Barre Syndrome

Treatments: Diagnostic Test: Peripheral nerve ultrasound; Diagnostic Test: Measurement of strength

Study type: Interventional

Funder types: Other

Identifiers

NCT04053452

Pro00102385

Details and patient eligibility

About

The purpose of this study is to determine if peripheral nerve ultrasound can be used as a supplemental tool to diagnose Guillain-Barre syndrome (GBS) in the acute setting and aid in prognostication.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• For GBS group: Inpatients with acute, progressive weakness and no alternative diagnosis, with onset less than 30 days prior to examination.
• For control group: Hospitalized patients on the inpatient neurology service who are being treated for non-peripheral nerve disorders (e.g. epilepsy, multiple sclerosis, or stroke).
• For all subjects: 18+ years of age

Exclusion criteria

• Patients with any history of multifocal motor neuropathy (MMN), prior Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), or hereditary neuropathy (e.g. Charcot-Marie-Tooth)

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

GBS Patients

Experimental group

Treatment:

Diagnostic Test: Measurement of strength

Diagnostic Test: Peripheral nerve ultrasound

Controls

Active Comparator group

Treatment:

Diagnostic Test: Peripheral nerve ultrasound