Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications (MIRPROT)

HaEmek Medical Center, Israel

Status: Terminated

Conditions: Depression

Study type: Observational

Funder types: Other

Identifiers

NCT01681407

EMC-07411-CTIL

Details and patient eligibility

About

A pilot study of mapping the peripheral plasma micro-RNA and proteomics patterns in depressive patients, treated with SSRI medications. It is an observational clinical bio-markers laboratory controlled research with no device.

The research includes two groups; one for patients diagnosed of having depression, and will get a standard SSRI medication regimen. Second group is for control subjects without depression. An option for a third group is planned to include first degree relatives of the depressed patients. After giving their informed consents, subjects and patients will go through standard clinical psychiatric interview, and routine clinical lab tests. Clinical standard, specific depression and anxiety questionnaires will be held at four follow-up meetings: at start; after 2 weeks; 4 weeks; and 10 weeks. Subjects and patients will be asked to give blood samples at these points of time for the lab processing: Complete plasma proteomics and specific micro-RNA levels.

Enrollment: 17 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Depressed patients,over 18 yo
• Untreated with SSRI, in the last 3 months

Exclusion criteria

• Bipolar patients or another major psychopathology
• Depressive disorder clearly due to general medical condition, or drug related
• BMI under 18.5 or above 40
• Pregnant patients
• Active suicidality

Trial design

17 participants in 3 patient groups

Depressed Patients

Description:

Patients: Group of patients that are diagnosed for having depression, and are suitable for SSRI treatment.

Non-Depressed Controls

Description:

Controls: Volunteers that had clinical screening with no depression diagnosis.

Patients Relatives

Description:

Patient Relatives (Optional group for later stage): First degree relatives with no depression diagnosis.