Peripheral Sensory Input in Central Post Stroke Pain (CPSP)

The Washington University

Status: Completed

Conditions: Central Post Stroke Pain

Treatments: Drug: Ultrasound-guided peripheral nerve block with 2% lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02148588

201405121

Details and patient eligibility

About

Prospective, open-label study in 10 patients with Central Post Stroke Pain (CPSP). The study will evaluate the effects of peripheral nerve blockade on spontaneous pain and evoked thermal and mechanical responses in CPSP, and assesses the associated local anesthetic pharmacokinetics.

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Each subject must meet all of the following criteria:

• Age ≥18;
• CPSP affecting an upper or a lower limb, in a distribution that may be completely covered by a peripheral nerve block;
• Patient fulfills all mandatory criteria for CPSP, fulfills at least one supportive criteria, and has definite CPSP by probability grading.
• Pain duration at least 3 months;
• Spontaneous pain intensity (average pain in past week) of ≥ 4 on 0-10 Numerical Rating Scale (NRS).

Exclusion Criteria

Subjects will not be enrolled if any of the following criteria exist:

• Not giving consent to participate in the study;
• Significant psychiatric or cognitive impairment;
• Moderate to severe renal or liver failure;
• Concomitant treatment with warfarin or other anticoagulants;
• Pregnancy or lactation.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Pain testing

Experimental group

Description:

Completion of NPSI questionnaire Sensory mapping of the affected limb Quantitative Sensory Testing Patients will have a peripheral nerve blockade

Treatment:

Drug: Ultrasound-guided peripheral nerve block with 2% lidocaine