Peripheral Vascular Function in Obstructive Sleep Apnoea

NHS Foundation Trust

Status: Completed

Conditions: Obesity; Obstructive Sleep Apnoea

Study type: Observational

Funder types: Other

Identifiers

NCT01619748

STH-16309

Details and patient eligibility

About

Peripheral vascular function is impaired in people with obstructive sleep apnoea who are untreated compared with age-, weight- and sex-matched healthy controls.

Full description

Obstructive sleep apnoea (OSA) is a chronic respiratory disorder associated with endothelial dysfunction, increased sympathetic activation and increased cardiovascular risk. The standard treatment paradigm is continuous positive airway pressure (CPAP), however, patient adherence to CPAP is variable. It is unclear to what extent that poor adherence to CPAP therapy augments vascular endothelial function and reduces cardiovascular risk compared to excellent adherence. The main aim of this research is to investigate vascular endothelial function in OSA patients who are poorly-adherent to CPAP therapy. Nitric oxide (NO)-mediated, endothelium-dependent macrovascular and microvascular function (by brachial artery flow-mediated dilatation and forearm cutaneous thermal hyperaemia, respectively) and generalised microvascular function (by post-occlusion reactive hyperaemia) will be assessed in three obese OSA patient populations (high-adherence (n=20); low adherence (n=20); and, untreated (n=20)) and age-/BMI-matched OSA-free controls. We will also assess body composition, cardiovascular risk, lipid status and functional capacity. This research will evaluate treatment efficacy in patients who are poorly-adherent to CPAP treatment and could identify whether an alternative approach to their care should be explored.

Enrollment: 45 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Obstructive sleep apnoea diagnosed using overnight polysomnography
• Age 18-90 years

Exclusion criteria

• Unable to perform the tests involved in the study
• Unable to provide written informed consent

Trial design

45 participants in 4 patient groups

Untreated OSA patients

Description:

Patients with obstructive sleep apnoea who are untreated

OSA patients highly compliant with CPAP

Description:

OSA patients established on CPAP therapy (high compliance, \> 80% nightly use for ≥ 4 h per night)

OSA patients poorly compliant with CPAP

Description:

OSA patients established on CPAP therapy (poor compliance, 10% \< nightly use \< 50% or \< 4 h per night)

Age and BMI-matched controls

Description:

Age and BMI-matched controls without OSA