Peripherally Inserted Central Catheter (PICC) Thrombosis: Reverse Taper Versus Non-tapered Catheters

University of Pennsylvania

Status

Completed

Conditions

Venous Thrombosis

Treatments

Device: Non-tapered PICC

Device: Tapered PICC

Study type

Interventional

Funder types

Other

Identifiers

NCT00728819

807264

Details and patient eligibility

About

The purpose of this study is to compare two different marketed PICC (peripherally inserted central catheter) designs. Clotting rates, procedural bleeding and ease of catheter insertion will be compared. It is hypothesized that the non-tapered design has a lower clotting rate and is easier to place than the tapered design. Bleeding rates are expected to be about the same.

Enrollment

339 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All inpatients, age 18 to 90, in need of de novo central venous access with a double lumen catheter indication of > 2 weeks
Informed consent and HIPAA consent forms discussed and signed by patient or their authorized representative

Exclusion criteria

Skin related problems around the insertion site (infection, phlebitis, scars)
History of mastectomy/axillary dissection on insertion side
Coagulopathy with an INR of > 2.0
Thrombocytopenia with platelets < 25,000 uL
Renal insufficiency with a creatinine of > 3.0 mg/dL
Documented current upper extremity or central venous thrombosis
Hypercoagulable states (protein C or S deficiency, AT-III deficiency, lupus anticoagulant)
Catheters needed for therapy within less than an hour (emergent placement not allowing sufficient time for proper research consent and randomization)
Patient has already been enrolled in this research study
Life expectancy less than 1 month