Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics

Baxter

Status: Unknown

Conditions: Dialysis; End Stage Renal Disease

Treatments: Other: no intervention

Study type: Observational

Funder types: Industry

Identifiers

NCT03964701

98550

Details and patient eligibility

About

Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis

Full description

Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis. Identification of peritoneal membrane functional status changes over time, at the same patient (cohort study), by metabolomics, aiming in personalized medicine best practice.

Identification of peritoneal membrane functional status changes over time in immature infants' peritoneal membrane.

Identification of early and accurate markers of peritoneal membrane dysfunction when membrane status is possibly reversible that could predict peritoneal patients at risk for future loss of ultrafiltration and dialysis adequacy of small molecules examined today be PET, KT/V and Cr/Cl (when membrane status is not reversible).

Improve PD survival in infants and children.

Enrollment: 18 estimated patients

Sex: All

Ages: 30 days to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric and adolescent patients on peritoneal dialysis
• Aged:1month -20 years

Exclusion criteria

-Abdominal surgery