Permian Health Women's Lung Health Study (WLHS)

Permian Health Lung Institute

Status: Not yet enrolling

Conditions: Alpha 1-Antitrypsin; COPD; Lung Function Decreased

Study type: Observational

Funder types: Other

Identifiers

NCT06029543

WLHS2023001

Details and patient eligibility

About

The goal of this cross-sectional observational study is to estimate the prevalence of lung function impairment as measured by spirometry in a population of Gambian women aged 15 and older. The main question[s] it aims to answer are:

• What is the prevalence of lung function impairment in Gambian women
• What is the prevalence of eosinophilic inflammation in Gambian women

Consenting participants will undergo

• Spirometry
• Fractional exhaled nitric oxide (FENO) testing
• α1-antitrypsin testing in patients with lung function impairment as assessed by spirometry

Enrollment: 350 estimated patients

Sex: Female

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Self-identified female sex
• Age > 15 years: This age cutoff was chosen (as opposed to 18) because of the unique cultural norms and practices in the country where experiences and exposures occur at an earlier age than women in Western countries.

Exclusion criteria

• Age < 15 years
• Non-resident household member
• Any acutely unwell individual
• Pregnancy
• Any known history of active pulmonary disease (including TB) on treatment.
• Individuals unable or unwilling to give consent.

Trial design

350 participants in 1 patient group

Gambian Women

Description:

Gambian women aged 15 and older with lung function impairment as measured by spirometry