Persistent Atrial Fibrillation Ablation Trial (PAAT)

Neil Sulke

Status: Suspended

Conditions: Atrial Fibrillation

Treatments: Procedure: Surgical AF ablation; Procedure: Percutaneous AF ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT01891825

PAAT

Details and patient eligibility

About

Persistent atrial fibrillation (AF) is a common and distressing condition, that can cause significant symptoms. AF ablation is a recognised technique to treat persistent AF, but can be technically difficult. This study compares percutaneous ablation to thoracoscopic surgical AF ablation.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Symptomatic persistent or long-standing AF suitable for AF ablation.
• Age over 18 years old.
• Informed consent to participate in this study.

Exclusion criteria

• Pre-existing ILRs or permanent pacemakers that do not allow for continuous monitoring for AF occurrence, or are not MRI-safe.
• Unable to undergo general anaesthesia for AF ablation.
• Previous cardiac surgery, such as coronary artery bypass grafting or valvular surgery.
• Scheduled for elective cardiac surgery, such as coronary artery bypass grafting or valvular surgery.
• Previous thoracic surgery.
• Participation in a conflicting study.
• Potential participants who are mentally incapacitated and cannot consent or comply with follow-up
• Pregnancy
• Other cardiac rhythm disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Pecutaneous AF ablation

Active Comparator group

Description:

Percutaneous catheter ablation of atrial fibrillation

Treatment:

Procedure: Percutaneous AF ablation

Surgical AF ablation

Active Comparator group

Description:

Minimally invasive thoracoscopic surgical ablation of atrial fibrillation

Treatment:

Procedure: Surgical AF ablation