Persistent Post Surgical Pain After Total Knee Arthroplasty

Policlinico di Monza SpA

Status: Enrolling

Conditions: Knee Arthropathy

Treatments: Procedure: continuous peripheral nerve block

Study type: Interventional

Funder types: Other

Identifiers

NCT06182059

PPSP PTG

Details and patient eligibility

About

Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this latter technique may reduce persistent postoperative pain six months after surgery

Full description

Patients undergone to primary total knee replacement with spinal anesthesia are randomized to receive a continuous adductor canal block infusion + an ipack block or a continuous femoral nerve block + a continuous sciatic nerve block just at the end of surgery. Both group will receive a multimodal analgesia with paracetamol, ketorolac, desametasone and morphine as a rescue.

Enrollment: 436 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary total knee replacement with a written informed consent

Exclusion criteria

• Allergy to local anesthetics or any drugs involve in the study
• Controindication to regional anesthesia
• chronic use of opioids
• BMI > 35 kg m2

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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436 participants in 2 patient groups

fast track

Active Comparator group

Description:

continuous adductor canal block and ipack block

Treatment:

Procedure: continuous peripheral nerve block

traditional

Experimental group

Description:

continuous femoral nerve block and continuous sciatic block

Treatment:

Procedure: continuous peripheral nerve block