Persistent Pulmonary Artery Hypertension After Valve Replacement (SALT)

University Hospital Bonn (UKB)

Status: Unknown

Conditions: Persistent Severe PH After Valve Therapy

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01238731

UKB_001_2010

Details and patient eligibility

About

Background: Persistent severe pulmonary hypertension (PH) after mechanical valve replacement is a frequent finding in patients with severe valve-diseases. The reasons to develop PH are multifactorial and the prevalence of severe PH significantly worsens the patients´ outcome.

Aims: (i) To define the prevalence of PH in patients after valve replacement and (ii) to identify factors predicting persistent PH.

Methods: All patients which underwent valve replacement at our institution between the years 2008 -2010 will be screened retrospectively. Those patients with pre- procedural proven PH by means of right-heart catheterization will receive prospective follow-up with echocardiography. Diagnosis of persistent PH will be confirmed with right heart catheterization.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Proven pulmonary hypertension before valve replacement and informed consent for data acquisition

Exclusion criteria

• patients do not meet inclusion criteria

Trial design

300 participants in 1 patient group

Valve replacement

Description:

Patients undergoing valve replacement for severe valve disease will be screened for study entry