Personal Precise Treatment on Psoriasis and Psoriatic Arthritis

Taichung Veterans General Hospital

Status: Not yet enrolling

Conditions: Dermatologic Disease

Treatments: Diagnostic Test: Markers data from PBMCs

Study type: Interventional

Funder types: Other

Identifiers

NCT04915105

CE20043B

Details and patient eligibility

About

Part of psoriasis and psoriatic arthritis patients treated with biologics and met primary failure. Therefore, we are going to create a cell based platform to evaluate the treatment effects of different biologics on psoriasis and psoriatic arthritis patients before prescribed by physicians

Full description

PBMCs isolated from psoriasis and psoriatic arthritis and incubated with Group A streptococcus and different biologics for 24 hours. Cytokines expression in the culture supernatants will be measured and the data can be reference for physician's prescription.

Enrollment: 90 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1. Healthy control without underline disease such as psoriasis and psoriatic arthritis. 2. Psoriasis been diagnosed for over six months and PASI >10. 3.Psoriatic arthritis been diagnosed for over six months and >1 swallow and tender joints

Exclusion criteria

• nil

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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90 participants in 1 patient group

Prescreen on psoriasis and psoriatic arthritis treatment

Experimental group

Description:

Prescreen markers from individual PBMCs and choose proper biologics before starting treatment on psoriasis and psoriatic arthritis patients.

Treatment:

Diagnostic Test: Markers data from PBMCs