Personalized Antidepressant Adherence Strategies For Depressed Elders (TIP)

Weill Cornell Medicine (WCM)

Status: Completed

Conditions: Depression

Treatments: Behavioral: TIP

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01301859

1R01MH087562-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The study is a randomized controlled trial to test the usefulness of a brief intervention to improve adherence to antidepressant medication prescribed to older adults in a primary care setting. Study will be conducted at Weill Cornell and University of Michigan.

Full description

The intervention is a brief, psychosocial intervention designed to be an adjunct to pharmacotherapy prescribed by a primary care physician. It includes psychoeducation, problem solving and development of goals and a personalized adherence strategy. The intervention includes three 30 minute sessions during the first 6 weeks of treatment and a follow-up phone call two weeks later.

Enrollment: 231 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age: 65 and older; Newly prescribed antidepressant medication by PCP (within past 10 days); Has not been prescribed antidepressant medication in previous 6 months.

Exclusion criteria

High suicide risk, i.e. intent or plan to attempt suicide Presence of alcohol abuse, substance abuse, psychotic disorder or, bipolar disorder as observed on the SCID, are excluded; Dementia: MMSE below 24, clinical assessment, or medication; Inability to speak English; Aphasia interfering with communication; Terminal illness or current chemotherapy

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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231 participants in 2 patient groups, including a placebo group

TIP Adherence Intervention

Active Comparator group

Description:

The TIP program is a brief, individualized intervention designed as an adjunct to pharmacotherapy for depression prescribed by a primary care physician. The key to the intervention is the involvement of the older adult in creating an adherence strategy tailored to his/her barriers and needs.

Treatment:

Behavioral: TIP

Usual Care

Placebo Comparator group

Description:

Treatment as usual in a primary care setting

Treatment:

Behavioral: TIP