Personalized Lifestyle Intervention and Weight Control

NaNa Keum

Status: Completed

Conditions: Weight Loss

Treatments: Behavioral: Non-obesity-related genetic information disclosure; Behavioral: Obesity-related genetic information disclosure with tailored lifestyle recommendations

Study type: Interventional

Funder types: Other

Identifiers

NCT04079972

2018-12-006

Details and patient eligibility

About

This trial aims to investigate whether tailored lifestyle consultation through SNP testing leads to more effective weight loss among overweight or obese individuals compared to general lifestyle guidance for weight control.

Enrollment: 53 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Korean adults aged 18 years and older who are interested in weight management through dietary and/or exercise therapy.
2. Individuals who are able and willing to participate consistently for the entire 2-year study period.

Exclusion criteria

1. Individuals with any illness requiring regular medical treatment in a hospital.
2. Individuals currently taking long-term prescribed medications.
3. Individuals diagnosed with eating disorders or mental illnesses (e.g., depression, panic disorder) by a physician.
4. Individuals who have undergone gastric surgery for weight loss.
5. Individuals who have undergone heart surgery or cancer surgery.
6. Individuals with severe anemia.
7. Individuals who are unable to engage in physical exercise.
8. Pregnant or breastfeeding women, or those planning to become pregnant within 2 years.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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53 participants in 2 patient groups

Disclosure of obesity-related genetic risk with tailored lifestyle recommendations

Experimental group

Description:

Participants received their obesity-related genetic test results, including variants in FTO (rs9939609), MC4R (rs17782313), and BDNF (rs6265), along with genotype-tailored lifestyle recommendations. The counseling materials encouraged risk-allele carriers to adopt healthier behaviors such as reducing fat intake, limiting snacking, and avoiding emotional eating. Personalized genetic results and recommendations were delivered at baseline through a user-friendly report.

Treatment:

Behavioral: Obesity-related genetic information disclosure with tailored lifestyle recommendations

Disclosure of non-obesity-related genetic traits only

Active Comparator group

Description:

Participants received genetic test results limited to non-obesity-related traits (e.g., beauty-related genes). They did not receive any obesity- or metabolism-related genetic information or tailored lifestyle recommendations. The full obesity-related genetic results were disclosed only after completion of the final follow-up.

Treatment:

Behavioral: Non-obesity-related genetic information disclosure