Personalized Treatment for Patients With Premature Ventricular Beats

University of Oslo (UIO)

Status: Enrolling

Conditions: Ventricular Premature Complexes

Treatments: Procedure: Invasive cardiac electrophysiological study and ablation therapy; Diagnostic Test: Cardiac MRI; Diagnostic Test: Cardiopulmonary exercise testing; Diagnostic Test: Coronary angiography; Diagnostic Test: Transthoracic echocardiography; Diagnostic Test: Holter monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT04617717

153850

Details and patient eligibility

About

Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?

Enrollment: 224 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Patients referred for PVC ablation