Perspective Memory and Executive Functions in HIV+ Patients ((3514))

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: HIV Infections

Treatments: Other: Neuropsychological testing

Study type: Observational

Funder types: Other

Identifiers

NCT05752578

3514

Details and patient eligibility

About

The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition (mechanical cognitive abilities) and Cold Cognition (cognitive abilities supported by emotion and social perception). The main questions it aims to answer are:

• Do HIV+ patients have more impaired prospective memory than healthy subjects?
• Is there a greater influence of Hot Cognition on prospective memory than Cold Cognition? Participants will undergo a battery of neuropsychological tests: Memory for Intentions Screening Test (MIST), Montreal Cognitive Assessment (MOCA), Interpersonal Reactivity Index and Modified Five Point Test.

Enrollment: 100 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria HIV+:

• consent to participate in the study
• diagnosis of HIV
• Current antiretroviral therapy
• age >18 years
• native Italian speaker

Exclusion Criteria HIV+:

• age <18 years
• presence of major psychiatric disorders within the past 6 months
• additional neurological conditions that may impair the performance of the tests (Alzheimer's disease, Outcomes of head-brain trauma, cerebrovascular episodes)
• Alcohol and drug addiction within the past 6 months
• Additional medical conditions that may impair neurocognitive profile and functional abilities (cerebrovascular damage, cardiac problems with functional impairment, severe liver disease)

Inclusion Criteria HIV- :

• consent to participate in the study
• Absence of HIV infection (HIV-RNA negative)
• age >18 years
• native speaker of Italian

Exclusion Criteria HIV+ :

• age <18 years
• presence of major psychiatric disorders within the past 6 months
• additional neurological conditions that may impair the performance of the tests (Alzheimer's disease, Outcomes of head-brain trauma, cerebrovascular episodes)
• Alcohol and drug addiction within the past 6 months
• additional medical conditions that may impair neurocognitive profile and functional abilities (cerebrovascular damage, heart problems with functional impairment, severe liver disease).

Trial design

100 participants in 2 patient groups

Subjects with HIV infection

Description:

Both male and female subjects, over 18 years of age, on antiretroviral therapy, native speakers of Italian

Treatment:

Other: Neuropsychological testing

Healthy control subjects

Description:

Both male and female subjects, over the age of 18 years, no neurological or psychiatric conditions that would alter test performance, native speakers of Italian

Treatment:

Other: Neuropsychological testing