PET-CT Predicting Segement Specific Lymph Nodes Metastasis

Fudan University

Status: Enrolling

Conditions: Lymph Node Metastasis; Non Small Cell Lung Cancer; Positron Emission Tomography

Study type: Observational

Funder types: Other

Identifiers

NCT05970913

ECTOP-1017

Details and patient eligibility

About

This study is a multicenter prospective clinical study that aims to evaluate the predictive value of preoperative PET-CT results (such as SUV uptake, size of tumor lymph nodes, and differences in FDG uptake compared to surrounding tissues) for lymph node metastasis in patients with non-small cell lung cancer. During surgery, all patients underwent systematic mediastinal lymph node dissection. The final pathological results were used to assess the predictive value of PET-CT for segment-specific lymph node metastasis.

Enrollment: 280 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Solitary tumor, or multiple tumors with only ground-glass nodules (GGNs) apart from the primary lesion.
• Diameter of the primary lesion ≤5cm, with a CTR between 0.5 and 1.
• No enlarged mediastinal lymph nodes observed on preoperative contrast-enhanced CT.
• Pathological confirmation of non-small cell lung cancer (NSCLC) either before or during surgery.
• Systematic lymph node dissection performed during surgery.
• No prior radiotherapy or chemotherapy for initial treatment.
• No history of malignant tumors.

Exclusion criteria

• Locally advanced or distant metastasis.
• Pleural dissemination observed during surgery.
• History of malignant tumors.
• Received neoadjuvant therapy.
• Systematic lymph node dissection not performed during surgery.
• Histopathological examination reveals lung malignancies other than non-small cell lung cancer (NSCLC).