PET CT Re-Planning NSCLC (4DCT-PET)

University Health Network, Toronto

Status: Completed

Conditions: Lung Cancer; Non-Small Cell Lung Cancer

Treatments: Diagnostic Test: PET/CT Scans

Study type: Interventional

Funder types: Other

Identifiers

NCT03403127

08-0269

Details and patient eligibility

About

This study will see whether the addition of more frequent planning CTs during the course of radiation, and of Positron Emission Tomography (PET), a diagnostic test similar to CT, prior to and during a course of radiation may provide information that could potentially be used during the treatment to improve the initial radiation plan.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age equal to or more than 18 years old
• Patients with NSCLC consenting for radiotherapy to the primary tumor and / or mediastinal / hilar lymph nodes. Prescription doses should be 60Gy or higher.
• Chemo-RT patients of any stage of NSCLC
• Patients with a measurable tumor on CT scan.
• Patients who are able to lie supine for two consecutive 25 minutes sessions.

Exclusion criteria

• Trimodality patients who will have surgery within 2 months post RT
• Previous radiotherapy to intended treatment volumes.
• Patients with recurrent disease
• Active malignancy other than lung cancer
• Pregnancy
• Failure to provide written informed consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)