PET-CT to Assess Brain Damage in Cardiac Arrest Patients

Capital Medical University

Status: Not yet enrolling

Conditions: Brain Injuries; Cardiac Arrest

Treatments: Other: No interventions

Study type: Observational

Funder types: Other

Identifiers

NCT06660238

2024-9-26-836

Details and patient eligibility

About

This was a single-center, observational study. Patients with successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management. After successful return of spontaneous circulation (ROSC) for 72 hours and hemodynamic stability for 24 hours, the patients underwent positron emission computed tomography (PET-CT) examination after resuscitation. The supervising physician accompanied the patient and used monitors to monitor vital signs during the examination. Patients who were on ventilators were mechanically ventilated with a magnetic ventilator (HAMILTON-MRI, United States). In addition to conventional cerebral oxygen metabolism, cerebral blood flow, oxygen extraction fraction, cerebral blood volume and other indicators were added in this experiment. These indicators can evaluate the patient's cerebral metabolism, cerebral blood flow and cerebral blood oxygen damage degree. The neurological outcome was followed up 6 months after onset according to the cerebral performance category（CPC）.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 years.
• sustained hemodynamic stability for ≥24h.
• the patients were unconscious and not able to obey verbal commands. • Advanced life support and target temperature management within 6 hours of return of spontaneous circulation (ROSC).

Exclusion criteria

• Patients with hemodynamic instability.
• Patients who could not complete cranial PET-CT examination for special reasons. • Patients during pregnancy.
• Patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
• Patients whose family members did not agree to be enrolled.