PET / CT With 18F-FDG: Does it Optimize the I 123-MIBG Imaging Results in the Search for Discriminating Factors for the Implementation of an Implantable Defibrillator?

Centre Hospitalier Universitaire de Nīmes

Status: Terminated

Conditions: Defibrillators, Implantable

Treatments: Other: Addional imaging

Study type: Observational

Funder types: Other

Identifiers

NCT01258283

2008-007163-16 (Other Identifier)

PHRC-I/2008/VB-03

Details and patient eligibility

About

The main objective of this study is to determine among the patients included a subpopulation that does not need a defibrillator.

This will be done by comparing the number of discordant segments (mismatch) between patients who have a severe arrhythmia (ventricular tachycardia or ventricular fibrillation) with appropriate electrical therapy within 3 years of monitoring and others. "Mismatch" in the definition of this objective is the usual definition: score 3.4 in I123-MIBG (Iodine 123 metaiodobenzylguanidine) and PET at 0,1,2.

Enrollment: 6 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with ischemic heart disease with heart failure
• Patients who received myocardial perfusion scintigraphy
• Indication for the implantation of an ICD installed according to current recommendations : LVEF <30% and NYHA (New York Heart Association) stage II, III.
• The subject must have given his informed consent and signed consent
• The subject must be a member or beneficiary of a social security system

Exclusion criteria

• Pregnant or lactating women
• History of "open heart" cardiovascular surgery
• Inability to sign informed consent (patient under guardianship)
• Patients with diabetes mellitus
• Patient with proven dementia
• Person refusing to sign the consent
• Someone who already has an ICD at baseline
• Life expectancy less than one year (NYHA IV, other diseases such as neoplastic disease in an advanced stage)

Trial design

6 participants in 1 patient group

The study population

Description:

See inclusion and exclusion criteria.

Treatment:

Other: Addional imaging