PET-guided External Beam Radiotherapy in Differentiated Thyroid Cancer

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Completed

Conditions: Differentiated Thyroid Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT03191643

Thyroid-COBRA

Details and patient eligibility

About

Description of the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.

Full description

The role of post-operative external beam radiotherapy (EBRT) in differentiated thyroid cancer is still discussed considering the low clinical aggressiveness and the availability of ablative 131Iodine therapy. However, there is a subgroup of tumors which lose the ability to capture Iodine over time. This study wants to describe the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• detectable thyroglobulin (Tg),
• negative post-metabolic radiotherapy whole body scintigraphy,
• no surgical indications.

Exclusion criteria

• prior radiotherapy in the head and neck area
• pregnancy

Trial design

16 participants in 1 patient group

differentiated thyroid cancer

Description:

Patients with locally recurrent thyroid cancer, treated with radical radiotherapy after total thyroidectomy +/- central compartment and/or laterocervical lymphadenectomy, previously treated with one or more cycles of 131 Iodine-ablation (RAI) and TSH suppression.