PET Imaging Study of Recovered Anorexics

University of Pittsburgh

Status: Completed

Conditions: Anorexia Nervosa

Treatments: Drug: Fluoxetine

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00603018

PRO06110005

Details and patient eligibility

About

Several studies in the past suggest that individuals who have or had anorexia nervosa may have alterations in brain serotonin. Serotonin seems to play an important role in regulating anxiety, mood, and other symptoms found in anorexia nervosa. We will be using a technology called Positron Emission Tomography (PET), which is a method used to take pictures of the body, in this case, the brain. Study participants will undergo two baseline PET scans on the first day of the study. The women who have recovered from anorexia will then be given a medication called fluoxetine (also know as Prozac) to take for 8 weeks. At the end of the 8th week, they will return for a third PET scan. By comparing the brain scans, before and after fluoxetine treatment, we can understand more about how treatment with fluoxetine affects the serotonin receptors in the brain. We will be comparing brain serotonin system in women who have recovered from anorexia before and after medication in order to gain a better understanding of changes in the serotonin system associated with eating disorders. This study may help shed light on how to make fluoxetine a more effective treatment for anorexia nervosa.

Enrollment: 23 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Recovered from Anorexia Nervosa
• Not taking medication for emotional problems
• Regular menstrual cycle

Exclusion criteria

• Women who are pregnant or nursing
• Psychoactive medications in the past 30 days
• Neurological disorders.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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23 participants in 1 patient group

Annorexia nervosa

Experimental group

Description:

Participants recovered from anorexia nervosa before and after administration of fluoxetine

Treatment:

Drug: Fluoxetine