PET-MR for Prediction and Monitoring of Response to Neoadjuvant Chemotherapy in Breast Cancer

Seoul National University

Status: Completed

Conditions: Breast Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01190566

PET-MR Breast Cancer

Details and patient eligibility

About

The purpose of this study is:

To validate the efficacy of multiparametric MRI, FDG-PET, RGD-PET, and PET-MR fusion imaging in the prediction and monitoring response to neoadjuvant chemotherapy of locally advanced breast cancer patients.

To identify the optimal combination parameters of MR spectroscopy, diffusion-weighted MRI, dynamic contrast-enhanced MRI, FDG-PET, and RGD-PET in the prediction and monitoring response to neoadjuvant chemotherapy of locally advanced breast cancer patients.

To compare the performances of dynamic contrast-enhanced MRI using parametric response map analysis versus those of pharmacokinetic parameters (Ktrans, kep, or Ve) in the early prediction of pathological responsiveness to neoadjuvant chemotherapy in breast cancer patients

Full description

Enrolled women with breast cancers who had received an anthracycline-taxane regimen and subsequent surgery were prospectively enrolled. DCE-MRI and FDG-PET scan were performed before and after the 1st cycle of chemotherapy. MR imaging parameters and SUV on PET scan within a tumor were analyzed. Clinicopathologic (age, clinical tumor stage, hormonal receptor status, and surgery type) and imaging parameters were compared according to the pathological response.

Enrollment: 57 patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathologically confirmed breast cancer
• Clinical stage IIb, IIIa, IIIb, IIIc
• Must have measurable disease
• Performance status of ECOG 0-2
• Adequate, bone marrow, liver, heart, and renal function
• Who did not receive chemotherapy for breast cancer
• Must agree with and signed informed consent

Exclusion criteria

• Prior history of cancer besides breast cancer
• Active bacterial infection
• Pregnant or lactating women
• Psychological disease or seizure
• History of arrhythmia, congestive heart failure, myocardial infarct, or unstable angina
• Male breast cancer
• Who had a pacemaker or history of open heart surgery